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This study sought to identify actionable gene targets in sarcomas by selective targeting of the molecular networks that support the growth of Ras-driven sarcomas in mice.
A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as psoriasis and inflammatory bowel diseases (IBD), by selective targeting of TYK2.
A better understanding of the molecular intricacies of drug-resistant cells will help to design novel therapeutic strategies by selective targeting of CSCs and EMT-phenotypic cells through alterations in the expression of specific miRNAs towards eradicating tumor recurrence and metastasis.
This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation.
Antibody-mediated immunity can contribute to the control of both infectious and noninfectious diseases, in the latter case possibly by selective targeting of self molecules.
Targeting of proteins has attracted the most attention (20, 21), but many proteins are guided toward their final destination before translation begins by selective targeting of mRNA (22).
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This argument is further supported by the selective targeting of BT-474 cells in a background of excess MCF10a cells.
This hypothesis is supported by the observation that selective targeting of CypA provides positive effects on the mitochondrial bioenergetics.
The APC/C is a macromolecular E3 ubiquitin ligase that coordinates the progression of eukaryotic cells through mitosis, by the timely and selective targeting of protein substrates for 26S proteasome-mediated degradation through ubiquitylation (Harper et al, 2002; Peters, 2002).
They exemplify the power of understanding the role of a biological pathway by careful target identification and selective targeting of that pathway.
Reviewer #2: This study by Yang, Lee, and Sternson investigates the viability of selective targeting of NMDA receptor inactivation by unmasking the antagonist MK-801.
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