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We have now for the first time tested this hypothesis directly by selective suppression of BK channel activity, using BK−/− mice [27].
Repeated spreading depolarizations may enhance epileptic activities (Gorji and Speckmann, 2004) by selective suppression of GABAergic function (Kruger et al., 1996).
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Impact Statement: "We discover that two distinct types of inhibitory neurons increase the brain's sensitivity to unexpected acoustic signals, by amplifying selective suppression of cortical responses to frequent, but not rare sounds".
Gene expression profiles of selected cancer-related genes responsive to JQ1 reveal distinct and more limited transcriptional responses induced by MZ1, consistent with selective suppression of BRD4.
Thus, our data confer convincing evidence that PHLPP2 may have a key role in determining the fate of cell by favoring apoptosis through selective suppression of Nrf2-regulated cellular defenses.
Filtered spectra (also referred to as edited spectra) based on specific NMR pulse sequences enabled selective suppression of signals modulated by intrinsic metabolites properties, such as molecular tumbling rate, diffusivity, hydrodynamic radius, and aggregation extent [31, 34].
This selective suppression of exocytosis evoked by short (action potential-like) depolarizations correlated with dispersion of Ca2+-entry.
Kaplan et al. [ 38] demonstrated selective suppression of mutated ACVR1 by utilizing ASP-RNAi (allele-specific RNA interference) techniques.
We subsequently discovered that long-term exposure to FFAs results in a selective suppression of exocytosis elicited by brief (action potential-like) depolarizations.
H NMR spectra were recorded on a Varian Inova 500 (500 MHz) spectrometer using a pulse sequence for selective suppression of the proton signals for water by presaturation methods.
This selective suppression of lower frequencies in the case of glycerol is corroborated by scaling arguments.
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