Sentence examples for by selective disruption of from inspiring English sources

The characteristic fold of the protein molecules is assumed to exercise antimicrobial activity by selective disruption of microbial membranes.

By selective disruption of the one or the other of these sites in concatenated GABAA receptors, it recently has been demonstrated (Baur and Sigel, 2005) that chloride currents were potentiated by diazepam in both cases.

Petroff et al. [8] have shown that the increase in Ca2+ transient amplitude observed in rat LV myocytes subjected to sustained longitudinal stretch whilst embedded in agarose is associated with an increase in NO production and is abolished by NOS inhibition or by selective disruption of the eNOS gene [8].

Selective disruption of cytoskeletal actin by pharmacological tools has yet to be verified in the adult cell, yet evidence exists for modulation of several ionic currents, including ICaL, INa, IKATP, ISAC by actin microfilaments.

Selective disruption of HDR caused by BRCA1 deficiency is a target for synthetic lethality in combination with PARP inhibitors.

The selective disruption of tumour endothelium by FgnE indicates that this fragment may bind with greater affinity to activated tumour endothelium than quiescent endothelial cells in healthy tissues.

Peptide glycyl-L-phenylalanine 2-naphthylamide (GPN) produced a rapid and selective disruption of the vesicles labelled by acidic dyes, suggesting that they could be mainly lysosomes.

To achieve this second element of specificity, we selected for aptamers with slow dissociation rates (t1/2 >30 min) that allow selective disruption of non-specific (or non-cognate) binding interactions by using a large excess of a polyanionic competitor.

Our hypothesis is supported by previous studies using STAT3 inhibitor, demonstrating that a selective disruption of STAT3 dimerization resulted in its aggregation in perinuclear aggresomes, followed by a decrease in STAT3 phosphorylation and nuclear translocation.

Selective disruption of VEGFC binding to NRP2 by an anti-NRP2 blocking antibody also leads to the reduction of LEC sprouting but does not inhibit LEC proliferation (Caunt et al., 2008).

In particular, our findings resemble the phenotype of SRF−/− mice, which exhibited a selective disruption of LTD in hippocampal CA1 neurons paralleled by an inability to learn hippocampus-dependent tasks (Etkin et al., 2006).