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The vigor of motor output can be controlled by the graded activity of the same set of neurons [ 18], or by selective activation of different subsets of neuronal populations [ 19, 20].
Sanchez, C. et al. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
To determine whether the effects of neurokinin SP or NKB were mediated by selective activation of NK1 or NK3 neurokinin receptors, the ability of preferential non-peptide antagonists to block these effects was studied.
Only R2 can be elicited by selective activation of nociceptors [17].
Yoo et al. suggested that multi-contact nerve electrodes can be effective in achieving upper airway dilation and patency by selective activation of various branches of the hypoglossal nerve in eight beagles [15].
The Dkk4-regulated secondary hair pathway, like the Eda-dependent primary hair pathway, is further mediated by selective activation of Shh.
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The mechanism underlying this effect on the Aβ pathology was caused by the selective activation of ADAM17 by AF267B treatment, thereby shifting APP processing toward the non-amyloidogenic alpha-secretase pathway.
Chronic neurodegeneration is accompanied by an inflammatory response characterized by a selective activation of the microglial cells of the central nervous system (CNS) (1).
In this scenario, the beneficial effect of the TKI treatment specifically acting on leukaemic stem cells is neutralised by the selective activation of normal HSCs by IFN α that spares the leukaemic cells and induces an additional binding deficit of the normal cells.
Such responses commonly involve protein phosphorylation mediated by the selective activation of protein tyrosine kinases (PTKs), with further modulation by tyrosine phosphatases (PTPs).
Thus, by the selective activation of HPTU reaction using Cr III) - 1,10-phenanthroline and Cr VI) - 2,2′-bipyridyl in acidic and basic pH ranges, the chromium species can be determined (Figure 2a,b).
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