The ML estimation is given by selecting the (x0,s 1,s 2inner,y0,s 1,s 2inner) among different itineraries {s 1,s 2} which minimizes the outer minimization in (34).
After energy minimization of the periodic models, molecular clusters were extracted representative of the monodentate, bidentate binuclear, and outer-sphere configurations by selecting the three Fe-octahedra and H-bonded H2O molecules nearby the chromate of interest.
The number of hidden layers and neurons was established by training different feed-forward networks of various topologies and selecting the optimal one based on minimization of the performance function mean square error (MSE).
It is not clear, however, that criteria for selecting the weight distribution, such as the minimization of the Euclidean norm, are biologically meaningful.
It is likely that subjects in the present study also attempted to minimize co-contraction, and that this minimization was done by selecting a limb posture that matched the intrinsic mechanical properties of the arm to the functional requirements of the task.
Phenomenological methods such as flux balance analysis (FBA), 59, 60 minimization of metabolic adjustment (MOMA), 34 and regulatory on/off minimization (ROOM), 15 can then be used to implement biological hypotheses that predict metabolic behavior by selecting one out of the multiple solutions of Eq. (1).
As we discussed previously [ 5], this analysis demonstrates a surprising degree of statistical heterogeneity, which remains despite minimal methodologic differences between the two trials and further minimization of clinical heterogeneity by selecting a more uniform subgroup of patients with severe sepsis and a high risk for death.
Optimal models were selected by minimization of the Euclidian distance between predicted and optimum release parameters.
The optimal design is selected based on the minimization of Total Annual Cost (TAC) for the overall system.
The effects of the selected strata in the minimization algorithm on the primary and secondary endpoints will be evaluated additionally.
