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During the 1960s, plant breeders working in Asia greatly increased rice yields by selecting for mutations in a gene called semi-dwarf1 (SD1), which shrinks the length of the plant's stem.
Floral structure has been modified by selecting for mutations of AGAMOUS (AG), a transcription factor that regulates floral organ identity.
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We alter gene expression on a genome-wide scale by selecting for dominant mutations in a randomly mutagenized general transcription factor.
This approach differs from traditional suppressor screens, which isolate single compensatory mutations, by selecting for combinations of mutations, which together significantly increase fitness.
The small number of P.G.D. centers selecting for mutations doesn't bother me greatly.
For example, floral timing has been modified in several plant species by selecting for natural TERMINAL FLOWER1 (TFL1) mutations.
On the contrary, by selecting for stability, we discourage some functional mutations, since functional positions are often thermodynamically destabilizing [85], [86].
Subsequently, the infected Ance mutant line is maintained over the CyO balancer background by selecting for flies with cinnabar eye color and curly wing mutations.
The fog-2 (q71) mutation was maintained during these introgressions by selecting for self-sterile hermaphrodites every few generations.
While RAF inhibitors are effective against melanomas with BRAF V600E mutations, they may induce keratoacanthomas and cutaneous squamous cell carcinomas by selecting for RAS-primed cells.
Second, genes can be selected for mutation burden by specifying the minimal or maximal number of samples containing a mutation in the same gene.
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