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This selection of features is often carried out by selecting a subgroup of the most differentially expressed genes [ 13] or in a multivariate fashion [ 12].
The vast majority (>97%) of the highly expressed promoters are of the broad type; broad promoters tend to regulate genes with a higher gene expression level than peak promoters), and thus by selecting a subgroup of highly expressed promoters, we could expect this group to contain more broad promoters than the total clustered set.
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As we discussed previously [ 5], this analysis demonstrates a surprising degree of statistical heterogeneity, which remains despite minimal methodologic differences between the two trials and further minimization of clinical heterogeneity by selecting a more uniform subgroup of patients with severe sepsis and a high risk for death.
Using a three-class (a) and two-class (b) subgrouping model, a minimal multiply-redundant methylation signature was identified by selecting a subset of signature candidates with the highest ranking in a classifier fusion model (support vector machine (SVM), artificial neural network (ANN), decision tree (DT) and Bayesian network (BN).
Begin by selecting a color of eyeliner.
Begin by selecting a mode of play.
By including only patients with EN and other specific criteria, the study by Jack and colleagues has selected a subgroup of patients at higher risk of diarrhoea.
We selected a subgroup of genes that we identified by their association with the main aroma-contributing volatiles, i.e., lactones and esters.
Theoretical sampling (Denzin & Lincoln, 2000), in which the objective of developing an explanation determines the specific criteria by which a sample is selected, was used to secondarily select a subgroup of PSWs for interview.
We selected a subgroup for blood analyses due to budget constraints.
Given ever increasing costs to develop a new drug and intense competition, adaptive enrichment designs are an attractive option for a development program that allows selecting a potential subgroup defined by a binary biomarker.
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