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The OR for the main effect of detection by screening was computed from the results of model #3.
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The PPV of the screening test was computed as the proportion of screen-detected cancers divided by the sum of false positives and screen-detected cancers.
Similarity between the virtual ligand and screening compounds was computed using the Manhattan distance metric.
The cumulative number of cervical cancer cases that have been prevented by screening over the available time span (1961 2010) was computed as the difference between the projected estimates based on APC model and cumulatively observed cases from NORDCAN (Engholm et al. 2010).
Scoring was computed by a probabilistic method.
The Gini was computed by Istat [ 39].
A dummy-coded variable was computed where 1 = had been screened for these cancers and 0 = never been screened.
A specificity of 90% was computed from a second study by Coste et al., conducted among French women undergoing routine cervical cancer screening [ 115].
RAS was computed daily.
This, in particular, concerns the last step of virtual screening where the binding free energy is computed by conventional molecular dynamics simulation.
Odds ratios (OR) for lack of previous screening and corresponding 95% confidence intervals (CI) were computed by unconditional logistic regression adjusted for 5-year age groups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com