Sentence examples for by screening of a from inspiring English sources
Small molecules potentially mimicking the hormone erythropoietin have been discovered by screening of a library of rationally designed multicomponent reaction molecules in a functional cell-based assay.
The technology was demonstrated by screening of a selected 23-compound fragment collection of documented binders, mostly amidines, using trypsin and thrombin as model target protease proteins.
Moreover, by screening of a SeSaM library S. mutans NADH oxidase 2 variants showing predominantly NADPH activity were found, giving further insight into cofactor binding site architecture.
Reengineering of construct design for clinical use has been achieved, including: new anti-HER2 scFv F5 generated by screening of a phage antibody library for internalizing anti-HER2 phage antibodies; modifications of the scFv expression construct to support large scale production and clinical use; and development of methods for large-scale conjugation of antibody fragments with liposomes.
We aimed to identify the cellular factor by screening of a cDNA expression library prepared from human lymph nodes.
By screening of a peptide phage display library, we previously identified profilin-1 as a binding partner for a diabetic aorta-specific phage in rats [8].
In conclusion, we have discovered a CDC25A/B-selective inhibitor, RE44 (10d), by screening of an RE-focused library with a nonacidic and nonelectrophilic enamine core structure.
A cDNA fragment of TaSK1 was originally isolated by screening of an embryonic cDNA library constructed by means of suppression subtractive hybridization method (SSH).
A second missense mutation, c.320T>C (p.I107T), was detected by screening of the gene in a Spanish patients cohort.
Hybrid cells producing human immunoglobulin were detected by screening of culture supernatants using a solid-phase enzyme-linked immunosorbent assay for human IgG or IgM.
Similarly, the binding preferences for internal PDZ binding motifs was profiled by screening of 24 PDZ domains against a nearly random octapeptide Y2H library [ 72].
