Sentence examples for by screening libraries of from inspiring English sources

Instead, modulators of the site at which γ−secretase cleaves APP have been developed by screening libraries of compounds, or noted by genetic manipulations [13], [17], [25].

Thus the complexes obtained by screening libraries of PB2 against these two different baits represent two common types of protein complexes (Fig. 6B): the PB1 C-terminal and PB2 N-terminal regions forms an inter-folded and stable structure while the PB2 C-terminal region and importin α1 dock together as pre-folded subunits.

The difficult task of finding the right insertion site to produce a biosensor can be accelerated by screening libraries of random GFP insertions [ 6- 8].

In a previous study, we found that ERGIC3 was a novel lung cancer-related gene by screening libraries of differentially expressed genes.

More recently, second generation antigen surrogates, and specifically ligands for CLL BCRs (M.S., J.M., and T.K., submitted), have been obtained by screening libraries of conformationally restricted oligomers, which bind proteins more tightly than the "floppy" peptoids.

Growth and development are controlled by a range of separate signalling pathways that can be probed at the molecular level by screening libraries of insertional mutants, constructed by restriction enzyme-mediated integration (REMI).

By iteratively screening libraries of a caffeine demethylase, we identified beneficial mutations that ultimately increased the enzyme activity in vivo by 33 fold and the product selectivity by 22 fold.

For instance, when the sequence of the peptide that binds the target is known, its affinity and selectivity can be increased by screening libraries created with limited mutagenesis of the peptide.

Finally, exploration of dendritic structural space by screening combinatorial libraries of peptide dendrimers for catalytic activity can lead to discovery of functional dendrimers with enzyme-like properties, in a process mimicking natural selection.

After finding one or more targets, the next step is to find potential drugs that block or change how the target causes or contributes to disease; this can be done by either designing a drug based on knowledge of the target's molecular structure and function, or by screening large libraries of chemicals and molecular compounds to find one.

Specifically, we first identified multiple overexpression targets by screening genomic libraries of E. coli in a sequential-iterative manner.