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This approach is helped by studying the mechanism of action of substances that produce effects on biological systems, as detected by screening a large number of compounds in animal models.
By screening a large scale RNAi library in human cells we have identified three novel genes that can regulate p53 function.
This could be tested by screening a large number of M. sylvestris accessions with markers linked to Dw1 and Dw2.
New LEA mutants with a high erucic acid content genetic background were obtained by screening a large B. napus EMS mutant population with TILLING [ 10].
The first strain was the most inhibitor tolerant strain identified by screening a large collection of yeast strains for tolerance to undetoxified acid-pretreated spruce hydrolysate.
In this study, we have identified a novel NSHL-causing mutation within the MIR96 gene by screening a large case control Italian population.
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These categories of genes would be interesting to approach by screening a large-insert library, but this library would likely prove to be frustrating when tandem repeat genes were cloned.
Given that the cleavage and fluorescence-signaling performance of MgZ were poorer when coupled with the ASAPs than with the unmodified substrate, the sensor performance might be further improved by screening a larger library of antisense elements via in vitro selection.
By screening a large-insert genomic DNA library, we sequenced and assembled 18,080 bp of A. argentata DNA including a complete open reading frame that is 13,440 bp long and predicted to encode a 4,479 aa A. argentata AcSp1 (Aar_AcSp1; Figure 1; GenBank KJ206620).
In this study, fragment screening by WAC with MS detection is demonstrated for the first time against a kinase target by screening a larger set of substances.
Misclassifications due to male-specific deletions can be detected by screening a larger set of individuals and by BAC screening and sequencing.
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by screening a small
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by screening a zebrafish
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