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The ATFs were identified by screening a combinatorial library of zinc finger-containing transcription factors for components that activated the transcription of a reporter gene under the control of a truncated GAL1 promoter from which the GAL4p-binding sites were deleted.
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We experimentally defined the optimal phosphorylation motif of the kinase OST1 by screening a semi-degenerate combinatorial peptide array [47].
Using a fluorescent binding assay, several small molecule inhibitors of MurG have been identified by screening of combinatorial libraries.
It opens new avenues for the design of novel anti-parasitic therapeutics by screening large combinatorial libraries of small compounds blocking the function of regulators of PfPP1.
This mechanism is reminiscent of the mode of action of small peptide inhibitors of phage λ site-specific recombination, which were isolated by screening synthetic combinatorial peptide libraries (Klemm et al, 2000).
Through screening a 9600-diversity combinatorial solution phase small molecule library, hit compounds with inhibitory activities against Etk were discovered.
By screening in a combinatorial manner the synthetic effects of aqueous compositions of 13 water-miscible solvents, we observe the emergence of hot spots of overall solvent polarity associated with very narrow product distribution.
Finally, exploration of dendritic structural space by screening combinatorial libraries of peptide dendrimers for catalytic activity can lead to discovery of functional dendrimers with enzyme-like properties, in a process mimicking natural selection.
In this work, a number of ionic liquid + catalyst combinations are screened using a combinatorial experimental technique with fructose, high fructose corn syrup, and glucose as a feed.
Peptide ligands binding to the autoprotease at 4 M urea were screened from a combinatorial peptide library.
To discover new synthetic materials, high throughput methodologies have been employed to screen a large chemical combinatorial space.
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