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Importantly, all of these measures of penetrance are intrinsically limited by sampling error and imprecision in defining disease prevalence.
Bronchial biopsy specimens can be limited by sampling error and small size.
Imaging is noninvasive and unencumbered by sampling error, and can provide sensitive information about infection location that may enable rapid diagnosis, facilitate monitoring and therapy.
Additionally, analysis of liver biopsy is often undermined by sampling error and inter-observer variation [ [ 6, 9- 15].
Endoscopic surveillance for Barrett's oesophagus (BO) is limited by sampling error and the subjectivity of diagnosing dysplasia.
Hickerson et al. [ 16] suggested the problem was caused by sampling error, and proposed as a solution an approximate-Bayesian model averaging approach that samples over empirically informed uniform priors.
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Finally, the validity of a social network analysis based on our ego-centric data collection methods may have been influenced by sampling errors and lack of representativeness [ 33].
Another major advantage of imaging is its ability to provide a holistic, three-dimensional assessment of the whole organ or body, less likely to be limited by sampling errors and therefore corelating well with the overall disease process.
However, the procedure is limited by sampling error, costs, risks to the patient, and the delay in getting results.
Contrary to a census, the results are sample estimates of the figures for the whole population and should be accompanied by sampling error estimations.
This low grade inflammation is, however, difficult to establish by conventional histology according to the Dallas criteria because the cellular infiltrates are often sparse and may be missed by sampling error.
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