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This is an essential challenge that needs to be addressed by robust study designs including normal and non-progressing controls when known to be appropriate.
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The methodological approach advocated by the Cochrane Effective Practice and Organisation of Care (EPOC) group will direct selection of the most robust study designs for the primary analyses.
Future studies should incorporate robust study designs to assist policy decisions.
Future research requires more robust study designs incorporating objective outcome measures.
This includes using robust study designs and evaluating team-training effects.
The proportions of uncommon, non-type A LPS in the primary episode of melioidosis in this study (1% in cases and 2% in controls) were similar to those observed in the previous study (3%) 9. Our findings, based on a much larger number of bacterial isolates supported by a robust study design, do not provide evidence for a link between uncommon, non-type A LPS and relapse.
By using a randomised clinical trial, we ensured a robust study design.
Further studies need to be conducted with robust study design to resolve heterogeneity in the current literature.
Robust study design based on mixed methods.
Robust study design based on multicentre nationwide randomised control trial.
Sensitivity analyses were stratified by the two major study designs in selected studies (24 crossover studies, 18 before and after studies), with crossover studies being considered the more robust study design.
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