Sentence examples for by robust activation of from inspiring English sources

We show that hypoxia significantly increases the surface expression of both LRP1 and eHsp90, thereby amplifying the eHsp90-LRP1 signaxisg axis, evidenced by robust activation of src, AKT and EphA2, accompanied by enhanced cell motility and invasion.

A recent study suggested that stem cells possess unique metabolic and proliferative properties that minimize insults to genomic integrity, which may be compromised by robust activation of DNA damage response in the long run (Mandal et al., 2011).

Our in vivo data reflect other studies using cells in culture where acute response to Tm is characterized by robust activation of all UPR target genes and, if this is sufficient to manage the stress, the UPR is downregulated.

The salient features of measles infections are characterized by a robust activation of the immune system and the generation of anti-viral responses, followed by a transient but profound immunosuppression to virus-nonrelated immune reaction [2], [3].

Both MDA-MB-231 and MDA-MB-468 cells were highly responsive to stimulation with either ligand as determined by a robust activation of ERK1/2 and Akt.

In the context here discussed, a tumor cell is deemed resistant when it "shortcuts", "compensates for" or "bypasses" receptor inhibition by establishing robust activation of survival pathways downstream of the EGFR or through other RTK signaling activation.

The subsequent release of cofilin from the plasma membrane and the continued suppression of LIMK1 by Kras/RAF1 together allow robust activation of the cofilin pathway.

However, incubation of lysates at 37°C induced a robust activation of caspase-1 activity that was inhibited by 130 mM/K+ as reported previously 20.

An increase in AMP ATP (e.g., caused by contractile activity or hypoxia) leads to robust activation of AMPK, which attenuates the translational signaling, while at the same time gene expression associated with high oxidative metabolism and mitochondrial biogenesis are enhanced and NF-κB proteasome-mediated degradatioNF-κB proteasome-mediated

The differences between these cells may be the result of a more robust activation of diverse signaling pathways activated by CXCR4 and the use of insensitive Gα chain used by CXCR4.

Both isoproterenol and PMA were found to provoke a robust activation of RACK1-associated PDE activity, which was completely ablated by co-incubation with GFX, indicating that the stimulation of PDE activity by both agents requires PKC.