The report — which strongly endorses the administration's standards while adding useful wrinkles of its own — suggests meticulous rig-by-rig inspections by government and third-party investigators.
A month ago, Mr. Bromwich told reporters he did not feel comfortable with a rig-by-rig approach because it could open up charges of favoritism.
Intriguingly, some viral variants can escape from host defense by avoiding being recognized by RIG-I.
Except for the endogenous RNAs recognized by RIG-I, there are abundant other cellular RNAs, such as mRNAs and rRNAs in the cytoplasm, which must utilize some unique strategies to avoid themselves being recognized by RIG-I.
Besides viral RNAs, endogenous RNAs, including various non-coding RNAs and ERVs, may be recognized by RIG-I (Fig. 1).
Given the deepened and broadened study of RIG-I, various RNAs have been found to be recognized by RIG-I, including classical viral RNAs and some endogenous RNAs.
Our findings thus define filamentous architecture as a common yet versatile molecular platform for divergent viral RNA detection and proximity-induced signal activation by RIG-I and MDA5.
Our work thus reveals that signal activation by RIG-I occurs by imprinting its helical assembly architecture on MAVS, a previously uncharacterized mechanism of signal transmission.
