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Tumors may be controlled by restricting the expression of OCT4, NANOG, and SOX2 or by disrupting the molecular pathways that are altered in CSCs.
We conclude that RhAG plays an important role in flower patterning and that low temperatures increase the petal number of rose flowers, at least partially, by restricting the expression of RhAG.
While the ability of cells to deal with exogenous DNA damage is not affected by restricting the expression of key DDT genes to the G2/M phase of the cell-cycle (Daigaku et al, 2010; Karras & Jentsch, 2010), other results suggest an early role for the Rad5 pathway during replication and SCJ formation (Branzei et al, 2008; Minca & Kowalski, 2010; Karras et al, 2013).
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As numerous metazoan elements display expression that is restricted to the reproductive apparatus, including the germ line and in surrounding somatic tissues, genomes have evolved specific mechanisms to protect these tissues by further restricting the expression of these elements.
To assure the high quality of negative data, we only chose the most confident up-regulated genes by restricting the differential expression p value, the fold change and consistency of the samples over time whenever available.
To this end, our data support a previous report by Zhang and colleagues [ 37], which proposed that Akt1 signalling promotes cell cycle progression of arrested pre-adipocytes by inhibiting FoxO1 and restricting the expression of its target genes including the cell cycle inhibitor p27kip1 [ 40].
Mesp2 also induced the expression of Ripply 1 and 2, which in turn played roles in restricting the expression domain of Mesp2 by suppressing the activity of Tbx6.
And the truth is that what Putin is doing in Russia now -- by restricting the freedom of expression -- is very similar to what I experienced being an entertainer in the former Soviet Union.
Oligo arrays have also been used for cross-species expression profiling by restricting the analysis to those probes that were perfectly conserved between the species analyzed [7].
These data are consistent with a model in which CHD4, a chromatin remodelling protein, facilitates cell fate specification by restricting the frequency of lineage-specific gene expression prior to specification in a cell-autonomous manner (Fig. 5D).
Thus the translation of c- fos mRNA acts as a trigger for its destruction, thereby limiting the expression of this oncogene by restricting the lifetime of its mRNA.
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