The first assessed potential misclassification of liver cancer cases by restricting the analysis to cases with clinical codes that indicated either a diagnostic examination (liver biopsies), treatment (chemotherapy, radiotherapy, or surgery), palliative care, and/or referrals to specialty care, and their matched controls.
In the first one, we assessed the accuracy of our case definition by restricting the analysis to the 265 cases with codes supporting the liver cancer diagnosis and 1002 matched controls.
The coding sequences downstream of the TSSs were removed by restricting the promoter sequences from -1000 to -1 of the TSSs.
FLBP is very slow compared to the rest of the descriptors but the naive implementation can be improved upon by restricting the belongingness computations to the possible subset of binary codes given a specific neighborhood.
In the case of ward CAs, the patient cohort was constructed by restricting the 'ICU admission source' field to 'patients admitted from the ward' and restricting the 'admission diagnostic codes' field to the APACHE (Acute Physiology and Chronic Health Evaluation) III 'non-operative diagnostic code 114 – post cardiac arrest'.
Unfortunately, even by restricting code types (i.e. inpatient vs. outpatient, primary vs. secondary) or using combinations of codes identification of HF patients using administrative data is imperfect.
Finally, we designed oligonucleotides for 765 more SNPs without restricting the SNP search to coding sequences as described by Werren et al. [26] (Table S11).
Although the raters disagreed concerning the significance of codes that were not clearly associated with cerebral haemorrhage or infarction, by restricting attention to those codes for which three or four raters agreed that acute stroke was probable, we were able to achieve consensus concerning the selection of codes.
Analyses were repeated for the DBD and RAM domain by restricting analyses to only those protein coding sequences corresponding to those regions as described on MicrobesOnline [ 41].
This restricts the possible binary codes, and as a consequent, restricts the amount of discriminative information that can be contained in the MBP descriptor.
