These results indicated that miR-4732-3p increrythroidthroid cell number by repressing the levels of SMAD2/4.
We have previously demonstrated that in mast cells with wild-type (wt) Kit, SCF regulates survival by repressing the levels of the proapoptotic BH3-only protein Bim.
These miRNAs may promote differentiation and granulopoiesis by repressing ABL2 levels, disrupting maintenance of the undifferentiated myeloid precursor state [ 5].
MicroRNAs (miRNAs) are short (about 22 nucleotides in length) single-stranded regulatory RNAs that modulate gene expression at the posttranscriptional level by repressing translation of specific messenger RNA (mRNA) targets, eventually resulting in downregulation of protein expression.
As in motorneurons, RPM-1 negatively regulates the pmk-3/p38 MAPK pathway in interneurons by repressing the protein levels of the MAPKKK DLK-1.
Indeed, it has been reported that lower concentrations of NAA (< 1 μmol·L− 1) enhanced the auxin levels by increasing the relative expression of YUC genes and CTL1 in bamboo and Arabidopsis, respectively (Wang et al. 2017 and b), while higher concentrations (> 5 μmol·L− 1) in liquid medium inhibited the auxin level by repressing the expression of YUC genes (Suzuki et al. 2015; Wang et al. 2017).
In mammalian cells, miRNAs predominantly regulate protein expression at a post-transcriptional level by repressing the translation of their target mRNAs (reviewed in [4], [5]).
Therefore, it is plausible to surmise that by repressing translation of Numb and p21WAF, high levels of Msi1 might promote aberrant cell proliferation and failure in differentiation and apoptosis.
The authors demonstrated that BAP1 regulates ferroptosis by repressing the expression of SLC7A11 gene leading to low levels of reduced glutathione and diminished antioxidant capacity of the cells.
For example, Chinmo/Bach2, which regulates nuclear actin levels also in vivo, maintains active cofilin by repressing the expression of the kinase Cdi (Tesk in mammals).
