Sentence examples for by repressing activation of from inspiring English sources
In spite of the fact that TGF-β is a key mediator in the pathological tissue fibrosis in many diseases [ 23], TGF-β is also known as a potent physiological immunomodulator in mammals that is able to inhibit Th2 and Th1 differentiation by repressing activation of GATA-3 and T-bet transcription factors, respectively [ 23].
When the estrogen-responsive region of the pS2 gene was used as a reporter in MCF-7 cells, however, PRB and not PRA repressed activation of the reporter by estrogen [ 10].
LXRs do not repress activation of the TRAM-TRIF-IRF3 arm stimulated by TLR3, consistent with MyD88 being the target.
COE suppressed MMP-9-induction by repressing transcription activation of the MMP-9 promoter.
Mdm2 may directly repress activation by both pRB and Sp1, or activation by NF-Y.
Specifically, SMG1 may maintain c-FLIP levels by repressing JNK activation that consequently prevents proteasomal degradation of c-FLIP, whereas NIK may maintain transcriptional levels of c-FLIP mRNA by activating both the classical and alternative NF- κB pathways.
Using mice with targeted mutation of the Siglecg gene, we demonstrate that Siglecg controls B1 B cell expansion in the peritoneal cavity by repressing NFκB activation.
We provide evidence that HuR facilitates endothelial activation by repressing expression of endothelial nitric oxide synthase (eNOS), a major source of nitric oxide, which potently inhibits leukocyte adhesion (Kubes et al, 1991).
The N1 helix might also contribute to regulation of the GTPase cycle and promote a step-wise activation by repressing GTPase activity in the monomeric form.
In addition, we show that Fezf2 promotes activation of Wnt/β-catenin signalling by repressing the expression of two negative regulators of Wnt signalling, namely lhx2 and lhx9.
Isoform expression is activated by downregulation of CTCF, upregulated by reduction in CpG methylation caused by inactivation of DNMT1 or DNMT3b, and repressed by activation of p53.
