Sentence examples for by renal function and from inspiring English sources

Simplified loading dose and maintenance dose regimens for each group stratified by renal function and weight were created to achieve Cmin 72 h and Css min of 15 μg/mL and 20 25 μg/mL, respectively.

The purpose of this study was (i) to determine the optimal dosage of teicoplanin for each patient group stratified by renal function and weight based on a population pharmacokinetic model and observed distribution of patient characteristics and (ii) to develop new simplified dosing regimens designed to achieve 15 30 μg/mL.

Dabigatran elimination is most influenced by renal function, and preoperative interruption should be based on creatinine clearance (CrCl) calculated according to the Cockcroft and Gault formula [ 10].

Moreover, the dynamic equilibrium concentration gradient is established by renal function and disappears, i.e. α → 1, only when renal function approaches zero [ 13].

The metabolism and clearance of cyclophosphamide and its metabolites have been shown to be influenced by renal function and increased concentrations are associated increased risk of toxicity in HCT.

Treatment of type 2 diabetes is difficult in patients with chronic kidney disease because most oral antidiabetic agents are affected by renal function and their use may be contraindicated in this patient population.

The results of this study indicate that clearance of digoxin and the creatinine clearance rate cannot be explained by renal function alone and that the validity of the Konishi equation for individualizing the digoxin dosage in Chinese patients is limited, being applicable only in stage 3 renal disease.

As the rates of mediator excretion may be influenced by renal function, weight and body size, values were related to creatinine excretion.

39– 44 In the elderly, gout is often accompanied by renal function impairment and urate excretion is often low to very low.

The CL of digoxin could not be explained by renal function alone, and the validity of the Konishi equation for individualizing the digoxin dosage in Chinese patients was only applicable in stage 3 patients.

Bleeding risk was also evaluated in subpopulations in which apixaban exposure could be altered by renal function, age, gender, and body weight as well as the combination of these factors.