Sentence examples for by regulating the subcellular from inspiring English sources
Downstream effectors in this pathway, Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), interact with the canonical TGFβ signaling cascade by regulating the subcellular localization of phosphorylated Smads [166, 167].
The dynamics of actin (assembly and disassembly) control SRF activity by regulating the subcellular localization of MAL (cytoplasm or nucleus) [16], [17].
PI3K signaling is known to be required for the establishment and the maintenance of cell polarity by regulating the subcellular localization and activation of downstream effectors that are essential for proper chemotaxis [3], [19].
Taken together, these data suggest that FGF2 treatment can antagonise BMP signalling by regulating the subcellular localisation of SMAD1 via the MAPK pathway in dissociated rat embryonic DSC cultures and that OLIG2 expression correlates with nuclear exclusion of C-term-pSMAD1.
In the nematode Caenorhabditis elegans, it is well established that AKT-1 controls dauer arrest and lifespan by regulating the subcellular localization of the FoxO transcription factor DAF-16.
JNK-1, the C. elegans homolog of mammalian JNK, is thought to regulate lifespan in parallel to the IIS pathway, by regulating the subcellular localization of DAF-16 [ 119].
Here we systematically investigated the mechanisms regulating the subcellular localization of GBPs.
Our results reveal a multipart mechanism regulating the subcellular localization of NFAT5.
Moreover, the control of caspase-3 p19 to p17 subunit conversion by cIAP2 can regulate the subcellular localization of active caspase-3, that is, p19/p12 complexes being cytoplasmic and p17/p12 complexes exhibiting the ability to relocate into the nucleus.
In mammalian cells, MAPK scaffold proteins facilitate the efficiency of signaling within the cascade by placing a kinase near its substrate and also regulate the subcellular localization of the signaling.
VE-cadherin, on the other hand, regulates the subcellular localization of N-cadherin by displacing it from the cell surface.
