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Previous investigations showed that many protein kinases modulated ion transport processes in living cells by regulating the activity of the corresponding ion transporters under ionic stress.
By regulating both the transcellular and paracellular pathways, the RPE regulates the ionic composition of the subretinal space.
Other critical molecules like pmKATP channels are involved in the cellular response by regulating ionic homeostasis under conditions of metabolic stress; although these channels have demonstrated cardioprotective effects, their role in regulating cell death pathways is limited.
It is the primary task of the kidneys to regulate the various ionic concentrations of the body.
All the results indicated that the properties of PBSI can be regulated by the ionic group distribution.
It has been suggested that Homer1a functions in neuroprotection after brain injury by regulating both mGluRs and ionic glutamate receptors.
Signaling is initiated in the cytoplasm by the SOS2/SOS3 calcium-responsive protein kinase pathway and transduced to the plasma membrane to regulate the Na+/H+ antiporter (SOS1) and reinstate ionic homeostasis.
In general, our study suggests that the silicate bioceramics could regulate immune responses by altering the ionic microenvironment between the implants and hosts, which may offer new insight about the mechanism of the bioactivity of silicate bioceramics in bone regeneration and provide profitable guidance for designing new biomaterials for bone tissue engineering.
The micro-pores were formed by acetylacetonate decomposition and decarboxylation, while their pore size was regulated by ionic and thermal induced cross-linking.
Lysosomal exocytosis is regulated by ionic events including Ca2+-dependent SNARE (SNAP (soluble NSF attachment protein) receptor) interaction [ 73] and it is possible that Cu interferes with some aspect of the SNARE function.
Self-assembly by SbpA is also affected by changing the ionic strength of the solution.
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