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The voltage-gated Kv1.3 channel plays a critical role in the pathogenesis of autoimmune diseases by regulating the functions of both T cells and B cells.
Given the relevance of microRNAs in muscle function and the emerging roles of circRNAs, we hypothesized that circRNAs may play key roles in processes such as muscle differentiation and regeneration, perhaps by regulating the functions of microRNAs or possibly other ligand molecules like noncoding RNAs, mRNAs, or RBPs.
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They play a major role in progression through the G1 restriction point [ 10, 12, 20] by regulating the function of pRb (retinoblastoma protein), which in its hypophosphorylated form (the functionally active form) can arrest cell cycle in G1 [ 12].
Nanodot arrays control astrocyte-astrocyte interaction by regulating the function of gap junction proteins.
To reveal the structural and functional mechanism of an enzyme, one needs to know its active site; to conduct structure-based drug design by regulating the function of an enzyme, one needs to know the active site and its microenvironment as well.
Similarly, the SIKs may also fine-tune NF-κB function in macrophages by regulating the function of histone deacetylase 4 (HDaclassa class II HDAC.
A relevant role has been suggested for leptin in immunity, not only by maintaining energy homeostasis but also by regulating the function of immune cells.
These results suggest that APS may be helpful in the resolution of liver fibrosis by regulating the function of immune cells in the liver.
IL-10 plays a predominant role in limiting immune and inflammatory responses by regulating the function of both macrophages and Th1 cells [ 1].
It has been proposed that the human RPA2 N-terminus may function by regulating the function of the human RPA1 N-terminus (Binz et al. 2003; Oakley et al. 2009).
To perform functions on such a broad spectrum, the cells have evolved multiple mechanisms regulating cellular Ca2+ levels, mainly by regulating the function of various Ca2+ channels present in different locations.
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