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They play a major role in progression through the G1 restriction point [ 10, 12, 20] by regulating the function of pRb (retinoblastoma protein), which in its hypophosphorylated form (the functionally active form) can arrest cell cycle in G1 [ 12].
To reveal the structural and functional mechanism of an enzyme, one needs to know its active site; to conduct structure-based drug design by regulating the function of an enzyme, one needs to know the active site and its microenvironment as well.
Nanodot arrays control astrocyte-astrocyte interaction by regulating the function of gap junction proteins.
Similarly, the SIKs may also fine-tune NF-κB function in macrophages by regulating the function of histone deacetylase 4 (HDaclassa class II HDAC.
These results suggest that APS may be helpful in the resolution of liver fibrosis by regulating the function of immune cells in the liver.
IL-10 plays a predominant role in limiting immune and inflammatory responses by regulating the function of both macrophages and Th1 cells [ 1].
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Protein acetylation plays a critical role in biological processes by regulating the functions and properties of proteins.
The voltage-gated Kv1.3 channel plays a critical role in the pathogenesis of autoimmune diseases by regulating the functions of both T cells and B cells.
Given the relevance of microRNAs in muscle function and the emerging roles of circRNAs, we hypothesized that circRNAs may play key roles in processes such as muscle differentiation and regeneration, perhaps by regulating the functions of microRNAs or possibly other ligand molecules like noncoding RNAs, mRNAs, or RBPs.
Originally, Coro1A has been isolated as an actin/myosin binding protein and implicated in F-actin dynamics by negatively regulating the function of the nucleation-promoting Arp2/3 complex (reviewed in [ 9]).
In addition, BAF60b may exert significant impacts on whole body energy homeostasis by regulating the development and function of the immune system and meta-inflammation.
More suggestions(16)
by establishing the function
by regulating the business
by regulating the release
by regulating the heat
by regulating the expression
by regulating the blend
by disrupting the function
by defining the function
by regulating the border
by regulating the chromatin
by regulating the water
by regulating the transcription
by regulating the speed
by regulating the pump
by regulating the balance
by regulating the peak
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