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While nano/micro patterns have been reported to be highly effective in modulating stem cell differentiation by regulating the cell affinity and extension, carbon-derived patterns are also capable of upregulating the differentiation of hMSCs.
In particular, we focused on the therapeutic aspects and potential of hUCBSC to control glioma cell proliferation by regulating the cell cycle.
Moreover, our results implicate TRAF4 in one of the emerging TJ-dependent signaling pathways that responds to cell polarity by regulating the cell proliferation/differentiation balance, and subsequently epithelium homeostasis.
This suggests a role of DDB2 as a tumor suppressor in normal cells, through protecting against cancer by regulating the cell cycle and by increasing apoptosis rather than by direct participation in the repair of DNA damage [19].
Our study provides evidence that the endo-siRNA pathway, previously thought to be non-essential during development, is essential to compensate against temperature fluctuations, specifically by regulating the cell cycle in the developing Drosophila embryo under environmental perturbations.
Loss of function studies utilizing conditional Shh and Smoothened (Smo) alleles indicate that Hh signaling acts by regulating the cell cycle of VZ stem and progenitor cells and in the absence of an active pathway there is significantly reduced neurogenesis, patterning defects and a smaller dorsal telencephalon at E18.5 [12].
Similar(42)
lsy-2 has previously been shown to be involved in the specification of the left-right asymmetry of ASE neurons by regulating the cell-type specific expression of lsy-6 miRNA (Johnston and Hobert, 2005).
Furthermore, EGCG may stimulate apoptosis in cancerous cells by negatively regulating the cell cycle to prevent continued division.
The accumulation of p16 contributes to senescence by negatively regulating the cell cycle in vitro and in vivo [18], [19].
It is conceivable that resident perivascular MSCs support the local ASC niche either directly by differentiating into tissue-specific cells as indicated above, or indirectly, by regulating the stem cell niche[123].
The above results imply that Stat5 and SHP-1 might contribute to dermatitis development by regulating the mast cell responsiveness to IL-3 (and other stimuli).
More suggestions(16)
by regulating the bias
by regulating the contact
by regulating the filter
by regulating the interaction
by regulating the number
by regulating the expression
by regulating the heat
by regulating the blend
by regulating the use
by regulating the function
by regulating the chromatin
by regulating the rotation
by regulating the balance
by regulating the activity
by depriving the cell
by regulating the development
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