Sentence examples for by regulating the activation from inspiring English sources
RAS maintains these cellular phenotypes by regulating the activation of multiple downstream effector pathways, including the RAF/mitogen-activated protein kinase (MEK /extracellular signal-regulated kinase (ERK) signaling pathway.
Increasing activating AMPK signals (AICAR or metformin treatment) is sufficient to overcome inhibition of Compound C suggesting that it does not directly inhibit the kinase activity of AMPK, but instead may act by regulating the activation of AMPK itself, which is likely based on its detrimental effect on AMPK phosphorylation14.
CDC25 phosphatases, which are believed to be important regulators of cell cycle progression, dominate entry into mitosis by regulating the activation of CDK1/cyclin B [ 5].
These data suggest that ERK contributes to the morphine-induced hyperalgesia by regulating the activation of c-JUN.
Since PKC, PKA or p90Rsk can also phosphorylate GSK3β at Ser(9) [31], it is likely that PP1cγ could affect GSK3β Ser9 phosphorylation by regulating the activation of one or more of these Ser/Thr kinases.
Low density lipoprotein receptor-related protein 1 (LRprotectsects against atherosclerosis by regulating the activation of platelet-derived growth factor receptor β (PDGFRβ) in vascular smooth muscle cells (SMCs).
We have previously demonstrated that this decorin-induced 62-kDa protein is expressed in most human tissues; it affects prostate cancer cell growth and cell death by regulating the level and activation of Hsp27 [13].
It is widely accepted that the UPR triggers the intrinsic pathway of apoptosis by regulating the expression and activation of Bcl-2 family members.
Given that BCR-ABL is the specific target of Gleevec, we surmised that Gleevec affects TA by regulating the expression and activation of telomerase via BCR-ABL.
In addition, cilostazol was shown to have an anti-inflammatory effect on neotissue at 2 weeks by regulating the recruitment and activation of monocytes.
Therefore, our results indicate that AG extract has a neuroprotective effect in ischemic conditions like a cerebral stroke by regulating the glial cell activation.
