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These results suggest that OCT1 contributes to malignant behaviours of GC cells by regulating synbindin expression.
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Since our group has identified synbindin as a pivotal regulator of ERK2 phosphorylation in GC, 9 we questioned whether OCT1 might affect ERK signalling by regulating synbindin.
They lie in non-coding regions and probably act by regulating the expression of nearby genes.
Indeed, by regulating the expression of Col25a1, miR-499 also participates to the fusion process.
Thus, the JNK pathway supports the survival of erythroblasts by regulating the expression of Bim.
We next addressed whether BRD9 exerts its function in pluripotency by regulating gene expression.
mTORC1 plays a critical role in promoting lipogenesis by regulating the expression of many lipogenic genes.
The products of the sirtuin genes work by regulating the expression of genes and modifying the activity of enzymes.
Tet1 controls meiosis by regulating meiotic gene expression.
Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression.
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