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Glucagon-like peptide-1 (GLP-1) controls glucose homeostasis by regulating secretion of insulin and glucagon through a single GLP-1 receptor (GLP-1R).
The exact mechanisms by which intranasal insulin may affect regional perfusion are not known but may include endothelium and nitric oxide (NO -dependent vasodilatatioNO -dependenton of vasodilatationon by regulandng secreduction endofhelin-1 (26).
To determine the molecular mechanisms of the anti-tumor and anti-angiogenic effects, we examined the direct anti-proliferative effects on human umbilical vein endothelial cells (HUVEC) and indirect effects by regulating secretion of angiogenic factors from HCC cells.
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Our laboratory has examined signaling pathways regulating secretion of inflammatory mediators by human airway smooth muscle cells.
3 This occurs in response to starvation, which triggers regulated secretion of chemoattractant by the amoebas (Fig. 1).
Results presented herein utilize a co-culture model with natively regulated secretion of human apoE by glia, the main endogenous source of apoE in the CNS.
Although all PKDs are regulated by a DAG-binding C1 domain and by an activation loop, they have been shown to regulate secretion of different cargo molecules.
Sieburth, D., Madison, J. M. & Kaplan, J. M. PKC-1 regulates secretion of neuropeptides.
Tsunemi T, Hamada K, Krainc D. ATP13A2/PARK9 regulates secretion of exosomes and alpha-synuclein.
When calcium was added to the incubation media to allow regulated secretion of both IRI and IAPP-LI, both BFA (47.7 micro 8.7 vs. 80.7 micro 10.3 pmol/l; P < 0.001) and CHX (37.3 +/- 5.8 vs. 73.3 +/- 6.2 pmol/l; n = 5; P < 0.0001) inhibited glucose-stimulated IAPP-LI secretion by approximately 40%, but again had no inhibitory effect on IRI secretion.
In addition to its anti-tumor effects, SST plays a role in maintaining intestinal homeostasis by regulating the secretion of intestine-associated hormones (e.g., pancreatic polypeptide) and intestinal motility [39].
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