Extracellular MMP inducer (EMMPRIN) was reported to involve in the progression of malignancies by regulating expression of VEGF and MMPs in stromal cells.
10.7554/eLife.02445.006 Figure 3. miR-1255b, miR-193b*, and miR-148b* regulate PARP inhibitor sensitivity by regulating expression of HR factors in TNBCs.
SOX18 regulates arteriovenous specification and developmental lymphangiogenesis by regulating expression of PROX1, and is found at low levels in the adult human brain.
MicroRNA-34a regulates SIRT1 expression both at the pre-transcriptional level, by regulating expression of transcription factor SP1 [ 16], and also at the post-transcriptional level, by binding to the 3' untranslated region (UTR) of SIRT1 transcript [ 28] to repress its expression.
Transcription factors play vital roles in plant adaptation to stresses by regulating expression of a great deal of target genes.
Preclinical studies indicate the immune modulatory effect of EGFR signaling by regulating expression of MHC I/II and PD-L1 on tumor cells and activity of lymphocytes.
Similar to Hd1, Hd5/DTH8/Ghd8/LHD1 delayed flowering in rice under LD and promotes flowering under SD, but by regulating expression of Ehd1 (Dai et al., 2012; Lin et al., 2003; Wei et al., 2010; Yan et al., 2011).
Gene ontology functional analysis of the differentially expressed genes indicates that surface modification of MPLA biomaterial has an extensive influence on cells by regulating expression of genes related to cell proliferation, cell cycle, cytoskeleton organization, ossification, bone remodeling, metabolism, and eventually induces osteoblast proliferation and differentiation.
A recent experiment reported that MFSD2A acts as a tumor suppressor in the lung by regulating expression of genes related to cell cycle and extracellular matrix [47].
The stem cell-specific transcription factors Oct4 and Nanog control ES cell pluripotency by regulating expression of stem cell specific genes and repression of differentiation-specific genes, of which a subset is co-occupied by PcG proteins [25], [43], [51].
Activation of FOXO may inhibit cell growth, proliferation and angiogenesis, and induce apoptosis by regulating expression of genes such as FasL, Bim, cyclin D1, p27 and TRAIL [39], [40], [56].
