Sentence examples for by regulating expression levels from inspiring English sources

We had shown that during zebrafish embryogenesis, eaf1 and eaf2/u19 mediated convergence and extension movements as well as midline convergence of organ primordia by regulating expression levels of the non-canonical Wnt ligands, wnt5, wnt11 and wnt11r [19].

These results indicate that Runx2 activates the Akt signaling pathway and cell survival by regulating expression levels and activity of mTORC2 complex in invasive breast cancer cells.

The EV-derived RNA may mediate MDR by regulating expression levels of drug efflux transporters or enzymes involved in lipid homeostasis, which would then disrupt the cellular signaling between the tumor and its microenvironment.

Because miRNAs execute their biological roles by regulating expression levels of target genes, we developed a whole-genome expression platform using RNA from EHBDs at the same time points after RRV challenge [GEO: GSE41595].

For protein coding genes, the central role of transcription initiation in regulating expression levels is well established.

Our results suggest that FAP enzymatic activity plays a role not only in regulating fiber orientation but also in regulating expression levels of collagen I.

We suggest that pulsatility, but not energy density, is crucial in regulating expression level of collagen I and integrin α5 in fibroblasts by ULLL.

The challenge of differentiated SK-N-BE human neuroblastoma cells with patho-physiologically relevant amounts of 27-OH and 24-OH showed that both oxysterols induce a net synthesis of Aβ1-42 by up-regulating expression levels of amyloid precursor protein and β-secretase, as well as the β-secretase activity.

MicroRNA-34a regulates SIRT1 expression both at the pre-transcriptional level, by regulating expression of transcription factor SP1 [ 16], and also at the post-transcriptional level, by binding to the 3' untranslated region (UTR) of SIRT1 transcript [ 28] to repress its expression.

The nuclear bile acid receptor, Farnesoid X Receptor (FXR), plays an important role in maintaining lipid and glucose levels by regulating expression of numerous metabolic genes mainly in the liver and intestine [ 46].

All these data suggest that PML RAR α affects ATRA signalling at multiple levels: first by regulating expression of the genes involved in transmitting the ATRA signals, second through an altered regulation of classical DR2-and DR5-containing RAR/RXR target genes and third through an extension of the (PML- RAR binding PML- RARl towards more degenerate DR-containing regulatory sites.