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Tyrosine phosphorylation may regulate Wave complex activity either by regulating conformation of the complex [37] or by regulating interactions among components of the complex such as Abi1 and Abl kinase [38] or Abi1 and the p85 regulatory subunit of PI-3 kinase [28].
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This could be controlled by regulating the conformation of 7SK or by post translational modification of HEXIM1.
These enzymes regulate the conformation of DNA by twisting and unwinding the double strands.
This later observation raises the possibility that the activity of the metabolic linker regulates the conformation of replication fork proteins by phosphorylation.
Silk nanofibers with different sizes and secondary conformations have been prepared in aqueous solution by regulating the self-assembly process of silk fibroin in order to provide structural units for further assembly.
Their avidity for DNA on a charge basis makes them ideally suited to regulate the conformation of DNA.
Voltage sensors regulate the conformations of voltage-dependent ion channels and enzymes.
While lack direct transcriptional activation capacity, these proteins regulate gene expression by changing the conformation of DNA and/or by direct interaction with several transcription factors (reviewed in [45]).
HEATs are seen to allosterically regulate the shape of proteins and allow multiple conformations and protein protein interactions controlled by elastic and tensor forces, mediated by tethers to cell structural components or organelles (4).
Pin1 is crucial for the stability of activated ERK and Akt, as it binds and regulates the phosphorylated conformation of those signaling proteins [ 60, 61].
Most interestingly, AT-hooks are also intrinsically disordered (Liu et al., 2006), and their phosphorylation by casein kinase II was proposed to regulate core promoter selectivity by altering the conformation of TFIID (Lewis et al., 2005).
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