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The blocks of conservation are separated by regions of variable sizes where genes show no conservation of order.
Colorectal cancer (CRC) is characterised by regions of variable hypoxia (Moulder and Rockwell, 1984).
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Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four α helices (αZ, αA, αB, αC), linked by loop regions of variable length (ZA and BC loops), which line the Kac binding site and determine binding specificity.
In eukaryotic mRNA the main protein coding sequence (MCS) is flanked by upstream and downstream regulatory regions of variable length and structure.
Different C-terminal regions of variable length were associated with the N-terminal RBB region shared by all sequences.
Structurally, these proteins are characterized by the presence of approximately 40 amino acids core region, which contains a glycine-histidine (GH) dipeptide at the N terminus and a tryptophan-aspartate (WD) dipeptide at the C terminus separated by a region of variable lengths [ 2].
Such methods are applicable to the solution of nonstationary flow problems that contain moving regions of rapid change in the flow variables, surrounded by regions of relatively smooth variation.
The HLH region contains two amphipathic α helices separated by a loop region of variable length.
The two domains are separated by a hinge region of variable length, which has been related to DNA and RNA binding [ 42, 53].
Altogether, these data show that the PIH1 homology region encompasses two structurally and functionally separable domains hereafter referred to as PIH-N and PIH-C which are linked by an intervening region of variable length and sequence.
This domain is divided into two regions, N-terminal consensus I (27 amino acids) and C-terminal consensus II (29 amino acids), which are separated by a hydrophobic region of variable length.
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