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Substituted amines and N-heterocycles, useful intermediates in industry, can be synthesized by reductive amination of ketones with amines in the presence of metal supported catalysts.
Grafting of CpRe(CO 3 units was achieved by reductive amination of formyl-CpRe(CO 3 with the peripheral amines of generation 3 and 4 PAMAMs to yield dendrimers labeled with a variable number of CpRe(CO 3 units, ranging from 8 to 14 for PAMAM-G3 and 17 30 for PAMAM-G4.
Test samples consisted of amphetamine synthesised by the Leuckart reaction, by reductive amination of benzyl methyl ketone and by the nitrostyrene route.
In this paper, we report the synthesis of a series of N-benzylated-2-aminoquinolines by reductive amination of aryl aldehydes with 2-aminoquinoline.
An alternative, two-step procedure requiring initial olefin hydroformylation, followed by reductive amination of the linear aldehyde intermediate, is also described.
Derivatives of N- 1-phenethyl-4-piperidyl propanamides iN- 1-phenethyl-4-piperidyl propanamidesdazoliN- 1-phenethyl-4-piperidyl propanamidesthetic approach iN- 1-phenethyl-4-piperidyl propanamides betweeN- 1-phenethyl-4-piperidyl propanamidesup by reductincorporating of piperidinone.
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NGL technology involves conjugating oligosaccharides by reductive amination to the aminolipid 1,2‐dihexadecyl‐sn‐glycero‐3‐phosphoethanolamine (DHPE).
Higher alkylated amines and amides were also synthesized respectively, by direct reductive amination of aldehydes with primary and secondary amines catalyzed by water soluble Pd(PhCN 2Cl2/BQC, and hydration of nitriles with [Rh(COD Cl]2/TPPTS.
Surface treatment with aldehyde silane followed by reductive amination with heterobifunctional amine-poly ethylene glycol)-camine-poly ethylenealent attachment of proteins to the particles usinglycol -carboxyldiimide chemistry.
The exergonicity of this conversion is coupled to the production of reduced nicotinamide and flavin coenzymes and nucleotide triphosphates directly, and into aspartate and glutamate synthesis by the reductive amination of TCA cycle intermediates oxaloacetate and α-ketoglutarate, respectively.
Labeling of glycans by reductive amination has several consequences for MALDI: the (secondary) aromatic amine group introduced in this reaction (see Fig. 2a) makes glycans labeled with PA, 2-AB, and 2-AA readily protonable.
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by reductive activation of
by reductive stabilization of
by reductive addition of
by reductive dehalogenation of
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by reductive removal of
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by asymmetric amination of
by reductive degradation of
by reductive enolization of
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by direct amination of
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