Sentence examples for by reductive activation of from inspiring English sources

These enzymes act on a variety of substrates [ 1, 2], and the reaction occurs by reductive activation of molecular oxygen coupled with decarboxylation of the co-substrate 2OG to succinate [ 3– 5].

We concluded that the catalytic activity is promoted by the reductive activation of O2 with H2 and the production of moderately agglomerated Agδ+n clusters on the catalyst surface.

The relevance of reductive activation of DOX by CPR for increasing cytotoxic activity of this drug towards sensitive human breast cell line MCF-7 has been also demonstrated using purified rat CPR (Bartoszek and Wolf, 1992).

The objective of this study was to examine the role of reductive activation of DOX by the human liver CPR in increasing its cytotoxic activity especially in regard to MDR tumour cells.

In this study, we investigated the role of reductive activation of DOX by the human liver CPR in increasing its cytotoxic activity against human promyelocytic leukaemia cells exhibiting two different phenotypes of MDR related to the overexpression of P-glycoprotein (HL60/VINC) or MRP1 (HL60/DOX).

The data presented in the study suggest that the reductive activation of DOX by exogenously added CPR constitutes a possibility to potentiate the activity of this clinically important drug against multidrug-resistant leukaemia cells.

Reduction of azo bond and reductive activation of pro-drugs at initial level is a crucial stage in degradation and detoxification mechanisms.

Fast reductive activation of MMC by CYP450R promotes the formation of ICLs.

The aim of this study was to examine the role of reductive activation of DOX by the human liver NADPH cytochrome P450 reductase (CPR) in increasing its cytotoxic activity especially in regard to MDR tumour cells.

The interaction of MMC with DNA can only occur following the reductive activation of MMC by various cellular reductases (Iyer and Szybalski, 1963), such as cytochrome P450 reductase (CYP450R) and DT-diaphorase (DTD – also known as NQO1).

It has been suggested that they could enhance cellulase activity by relieving product inhibition through the oxidation of cellobiose to cellobionic acid [ 34], and more recent work has demonstrated that CDH was able to act synergistically with AA9 in cellulose breakdown by coupling cellobiose oxidation to the reductive activation of AA9 proteins [ 35, 36].