Sentence examples for by reducing transcription of from inspiring English sources

For instance, by reducing transcription of the mutant DNA, they may reduce the amount of toxic mutant protein, and delay the onset of disease.

These results favor the interpretation that shits1 perturbs the clock by reducing transcription of at least two CLK-activated core clock components, per and vri, and that this leads to reductions in PER levels.

Inhibition of PI3K/Akt and MEK/ERK pathways can lower cell proliferation by reducing transcription of SKP2.

In conclusion, we suggest that ZEB1 is a crucial promoter of tumour progression by reducing transcription of both mRNAs and miRNAs.

Similarly, it is reasonable to speculate that Cd acts on megalin and ClC5 expression simultaneously and at two distinct levels: by reducing transcription of megalin and ClC5 mRNA, and by increasing megalin and ClC5 degradation through the lysosomal pathway.

141 Huang and colleagues have demonstrated that the topoisomerase topotecan can un-silence the paternal Ube3a allele in cultured mouse primary cortical neurons, apparently by reducing transcription of Ube3a-ats.

The activity of CDKs can be inhibited, on the other hand, by reduced transcription or enhanced degradation of cyclins, or by CDK inhibitor (CDKI) proteins from the Cip/Kip family or INK4 family.

Importantly, prior treatment of monocytes with anti-DR-DP-DQ antibody in ice followed by SEB stimulation significantly reduced transcription of MyD88 (data not shown) as well as TNF-α gene (Figure 1C) as detected by real time PCR indicating that SEB acts through HLA and not other surface components.

Indirectly, RNAIII reduces transcription of spa by inhibiting translation of Rot [17].

Preclinical work demonstrated that the histone deacetylase inhibitor hydroxamic acid analogue, LAQ824, significantly reduced HER2 levels in SKBR3 and BT474 breast cancer cells by promoting proteasome-dependent degradation and reduced transcription of HER2 [ 70].

Female mammals deactivate one of their two X chromosomes in order to approximate the gene dosages of males, C. elegans hermaphrodites (XX) reduce transcription of each X by about one half, and Drosophila male flies increase transcription from their single X chromosome about twofold [36].