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This conclusion is supported by reducing the viability of studied cells, especially 72 h after the treatment.
The purpose of this study was to test the hypothesis that the cytotoxic drug cis-platinum (CP) induces premature ovarian failure by reducing the viability of human granulosa cells.
In the present study, we observed that STE was involved in oral toxicity by reducing the viability of human squamous epithelial cells, SCC-25, along with the simultaneous induction of both apoptosis and autophagic signaling.
50 nM gemcitabine induced cytotoxicity in Mia PaCa-2, BxPC-3 and Capan-1 cells by reducing the viability to more than 50% while PANC-1 cells remained unaffected.
Cell proliferation was assayed by MTT method using Huh 7.5 cell-line to exclude any possibility that the elimination of the viral particles was caused by reducing the viability of the cells.
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As indicated in Table 1, S. dominica and S. syriaca exhibited clear cytotoxic effects by reducing the cells viability to less than 25% (P < 0.05).
Metronomic cyclophosphamide has also been reported to inhibit tumor angiogenesis, e.g. by reducing the mobilization and viability of HPCs and by inducing sustained apoptosis of endothelial cells within the vascular tumor bed [ 27- 32].
Overexpression of RCC's detoxifying enzyme, Pseudomonas AKR1 (PsAKR1) in tobacco and rice showed improved seed viability by reducing the levels of MDA, methyl glyoxal (MG), Maillard products and Amadori compounds under controlled accelerated deterioration conditions and improved seed viability and seedling vigour.
Surfactants may also improve the cell viability by reducing the unproductive binding of cells to fermentation residues.
It should also be noted that long-term induction of autophagy may reduce cell viability by reducing the cells' responsiveness to stress [ 50].
Modest losses of allelic diversity may also negatively impact long-term population viability by reducing the capacity of populations to adapt to altered environments.
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by decreasing the viability
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by reducing the uncertainty
by reducing the productivity
by reducing the issue
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