These approaches allowed us to demonstrate that CyaA expressed by B. pertussis strongly interferes with DC functions, by reducing the expression of phenotypic markers and immunomodulatory cytokines, and blocking IL-12p70 production.
It has been shown that treatment of an AS model mouse with the topoisomerase inhibitor topotecan can restore some UBE3A expression from the paternal allele, most likely by reducing the expression of the antisense that normally silences paternal UBE3A23.
These results indicate that rutin attenuates ischemic neural apoptosis by reducing the expression of p53, preventing morphological changes and increasing endogenous antioxidant enzymatic activities.
Our results show that GLP-1-SSM treatment markedly alleviated the colitis phenotype by reducing the expression of pro-inflammatory cytokine IL-1β, increasing goblet cells and preserving intestinal epithelial architecture in colitis model.
By reducing the expression level of the sialyltransferase gene and increasing that of the neuABC genes, we have been able to favour the formation of 6′-sialyllactose and to prevent the formation of KDO-lactose.
GSTT can interrupt the cascade in the process of apoptosis by reducing the expression of Caspase-3.
JNK2 prevents Ras-induced cell senescence and growth arrest by reducing the expression levels of the cell cycle inhibitor p16 and the activation of NF-kappaB.
AS exhibited significant anti-proliferative effects on naive CD4+ T cells by reducing the expression of cell surface protein CD25 (IL-2 receptorα chain) and CD69 [127].
For example, Sub1A-1 inhibits leaf elongation by suppressing the expression of expansin-encoding genes and restrains carbohydrate consumption by reducing the expression of α-amylose genes and sucrose synthase genes [39].
But researchers from the University of California, Los Angeles, found that mindfulness meditation helped to decrease these feelings of loneliness among the elderly, and boost their health by reducing the expression of genes linked with inflammation.
Next, we asked if inhibition of the Notch pathway affected BM-PC adhesion to ECM by reducing the expression of specific integrins.
