Sentence examples for by reducing the affinity from inspiring English sources

The release of bFGF from the surfaces was induced by reducing the affinity binding between bFGF and immobilized-heparin due to increasing the mobility of the swollen grafted P IPAAm-co-CIPAAm) chains.

Allostery further increases the effectiveness of ASO by reducing the affinity of the developing transpososome for the second transposon end.

One possibility is that cytokines may play a role in steroid resistance by reducing the affinity of GR [ 19].

DHA can inhibit AA metabolism and platelet aggregation by reducing the affinity of the platelet TXA2/PGH2 receptor.

Such stabilising mutations occur in domain II and act by reducing the affinity of the Aux/IAA for SCFTIR1, conferring pleiotropic auxin related phenotypes.

Our finding that OPI is relieved by reducing the affinity between the transposase and the transposon end provides a further explanation for the unexpected efficiency of this cross-mobilization in addition to their short length.

This is explained by reducing the binding affinity between the siRNA strands to the complex, thereby enabling siRNA release after cellular internalization.

Thus, an increased and more predictable tissue distribution can be achieved by reducing the tissue affinity of the infusate using appropriately engineered liposomes or other nanoparticles.

Zamponi and colleagues propose that PrPC bound to copper limits excessive NMDAR activity by reducing the receptor affinity for glycine.

However, mutations of C2610U and especially A2058G, both of which are present in H. marismortui, have been found to confer resistance to SB by reducing the binding affinity of the drug [ 31]; therefore, they provide a plausible explanation for the absence of SB from the H50S complex.

All these mechanisms result in polymyxin resistance by reducing the net negative charge of the outer membrane, thus reducing the affinity of polymyxin to the bacterial surface [ 38].