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Mammalian DPPIII exhibits particular affinity for the degradation of hypertension-inducing peptides via the inactivation and degradation of angiotensin II to angiotensin III; the consequential reduction in vasoconstrictor activity likely induces hypotension alongside thrombolysis, by reducing the activity of plasminogen activator inhibitors that constrain fibrinolysis [ 68- 70].
Insulin resistance is also associated with reduced clearance of VLDL particles and chylomicrons by reducing the activity of lipoprotein lipase, increasing levels of apolipoprotein C-III, and impairing apolipoprotein E-mediated clearance of triglyceride rich lipoproteins.
The potential mechanisms underlying these inverse associations between flavonoids and type 2 diabetes risk may include the modulation of the postprandial glucose levels by reducing the activity of digestive enzymes (e.g., α-amylase and α-glucosidase) (34) and decreasing the active transport of glucose across intestinal brush border membrane, inhibiting sodium GLUT2 (35).
Thus, HIF-1 not only regulates the supply of oxygen, but also actively regulates the oxygen demand of the tissues and cells by reducing the activity of the major cellular consumer of oxygen, mitochondria22.
A type of biguanide that can induce AMPK activity and can disrupt the electron transport chain by reducing the activity of complex I.
Further, the Mn addition appears to suppress the passivation process by reducing the activity of Cr-adsorbed species in an acidic solution, and hence the repassivation rate is significantly decreased with Mn content of the alloys.
Similar(6)
Further fuel supplies were made available to the heavy bombers by reducing the activities of USAAF fighter units based in China.
This leads to an interesting hypothesis – perhaps quorum sensing restricts the growth rate of S. glossinidius at high infection density by reducing the activities of enzymes involved in translation.
Every living organism relies on enzyme inhibitors as feedback signals that coordinate metabolic pathway activity: by reducing the catalytic activity of their respective enzyme targets, inhibitors throttle the flux of intermediates through a pathway.
Most of the centrally acting analgesics influence the locomotor activities by reducing the motor activity because of their CNS depressant property [ 66].
After exercising, participants cool down for 5 10 minutes by slowly reducing the activity.
More suggestions(18)
by reducing the support
by reducing the service
by decreasing the activity
by lowering the activity
by reducing the operational
by comparing the activity
by reducing the oxygen
by using the activity
by multiplying the activity
by influencing the activity
by reducing the response
by assessing the activity
by testing the activity
by examining the activity
by affecting the activity
by augmenting the activity
by reducing the porosity
by modulating the activity
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