Sentence examples for by reducing phosphorylation of from inspiring English sources
Simvastatin can attenuate basal stress fiber formation on pulmonary artery endothelial cells by reducing phosphorylation of myosin light chains [22].
Furthermore, C7ORF41 appeared to suppress NF-κB activity by reducing phosphorylation of p65 at serine 536, which contributes to NF-κB transactivation and increases p65 transcriptional activity.
Mechanistic studies exhibited that GA inhibited the production of HIF-1α by reducing phosphorylation of Akt and mTOR in U266 cells.
TNF- α inhibits AKT-mediated phosphorylation of FOXO1 in adipocytes by reducing phosphorylation of insulin receptor substrate-1 on tyrosine residues thereby diminishing the negative effect of insulin receptor signaling [ 26].
Downregulation of SPARC in glioma cells using short interfering RNA decreased tumor cell survival and invasion in vitro by reducing phosphorylation of AKT, FAK, and integrin-linked kinase [ 160].
PKC activation may also be important for H. pylori-regulation of the tight junction [ 65] as activation of PKC increases TER by reducing phosphorylation of MLC [ 81] and decreased TER in T84 colonic epithelial cells induced by H. pylori was prevented by concurrent activation of PKC using the phorbol ester phorbol 12-myristate 13-acetate (PMA) [ 65].
Our study demonstrates that miR-128-mediated inhibition of SIRT1 not only acetylates p53, but also increases acetylated FOXO3A and leads to nuclear translocation of FOXO3A (by reduced phosphorylation of FOXO3A).
While PLX-4032 effectively blocked oncogenic BRAF signaling, as measured by reduced phosphorylation of the downstream effector ERK1/2 (MAPK3/1; mitogen-activated protein kinase 3/1), autophagy was not significantly altered (Fig. 8B).
The reduction in lipolysis by IKKε overexpression was accompanied by dramatically reduced phosphorylation of HSL and perilipin in response to ISO or CL-316,243.
Depletion of ATR by shRNA reduced phosphorylation of H2AX in response to plasma treatment by 92% relative to non-targeting shRNA and 40% in response to hydrogen peroxide (Figure 8C).
Downstream events were consistent with previous in vitro studies by demonstrating reduced phosphorylation of JNK and c-Jun in the inflamed joints of MKK7 ASO-treated mice.
