Sentence examples for by reducing its expression from inspiring English sources

Thus, we investigated whether GPR83 may have a role in regulating core body temperature (CBT) by reducing its expression in the POA.

We examined the role of ETRB by reducing its expression level using small interfering RNA (siRNA).

When subjecting the killifish (Austrofundulus limneaus) to heat shock conditions, the killifish responded by reducing its expression of HMGB1 [ 45].

Therefore by direct inactivation of p53 or by reducing its expression via NDRG1, Sirt1 promotes cell resistance to oxygen deficiency in the placenta [ 1].

It is possible that this mutation affects non-coding sequences or a different gene that interacts with ATPalpha, possibly by reducing its expression (see Fig.  2b).

To further understand the significance of the aberrantly over-expressed TRPM7 in pancreatic cancer, we investigated the role of TRPM7 in cell invasion by reducing its expression.

Transient transfection of PAEC with a plasmid carrying the antisense PCMT significantly lowers the activity of the endogenous methyltransferase, by critically reducing its expression.

As an additional promising approach, we investigated whether pharmacological inhibition of EZH2 in RD cells by either reducing its expression or catalytically inhibiting its activity might be detrimental for cancer cell proliferation both in vitro and in vivo.

Similarly, ATCHX17 is a sodium/proton anti-porter and the gene for this protein was expressed 6.4 fold higher in Pistarv than in the control, subsequently reducing its expression level by 5 fold during recovery.

Chac1 knockdown by siRNA (siChac) significantly reduced its expression upon incubation with palmitate or with CPA (columns 5 and 6 in Figure 9E).

One gene in particular reduced its expression by about 50% with age in both human tissue and in rodents, the researchers report today in Science Translational Medicine.