Sentence examples for by reducing its affinity from inspiring English sources
The phosphorylation of PTP-PEST at S435 has no direct effect on its enzyme activity, whereas the phosphorylation at S39 decreases its activity, possibly by reducing its affinity for substrates [5].
For instance, the kinase Akt phosphorylates Ezh2, suppressing Ezh2 HMT activity by reducing its affinity for histone H3, leading to global loss of histone methylation at K27 (Cha et al, 2005).
Pathways, such as cAMP signalling that mediate bronchorelaxation, for example cAMP dependent PKA inhibits MLCK by reducing its affinity for Ca2+/CaM (reviewed in [ 27]), may also be differentially regulated in ASM from subjects with asthma versus health.
An attractive hypothesis was that Tyr1022Cys shifts GeaA1 localization towards the late Golgi, perhaps by reducing its affinity for an early Golgi receptor, and that this suffices to bypass HypB partially.
Furthermore, p53-mediated apoptosis induced by RITA was transcription-dependent, because it was totally halted by pifithrin (PFT)- α, a chemical inhibitor of the p53 transcriptional activity, but not affected by PFT- μ, which inhibits p53 binding to mitochondria by reducing its affinity to anti-apoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation.
HFE protein forms a stable complex with transferrin receptor (TFR), thereby reducing its affinity for transferrin (TF) by approximately ten fold [ 3].
When cells are stimulated to divide by extracellular signals, active G1-cyclin-dependent protein kinase (Cdk) accumulates and phosphorylates Rb, reducing its affinity for E2F.
In bacteria, ClpS binds to ClpA reducing its affinity for unfolded polypeptides [ 42].
Conclusion: Compared with the linear peptide, cyclization negatively affects the biological properties of NAP-NS2 peptide by reducing its binding affinity for MCR1R (Ki: 0.9±0.3 nM for NAP_NS1; 7.1±2.4 nM for NAP_NS2) and decreasing the overall excretion rate of the corresponding [99mTc(N)(PNP3)]-labeled peptide from the body as well as its stability.
Phospholamban (PLN) is a small, 52-residue SR protein capable of physically interacting with and inhibiting SERCA activity by reducing its apparent affinity for Ca2+ (Morita et al., 2008).
Phosphorylation of eIF4EBP by mTOR reduces its affinity for eIF-4E and promotes the initiation of protein synthesis from a pool of transcripts enriched in mRNAs encoding proteins involved in angiogenesis, growth, and survival.
