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Chungsimyeonja-eum (CSYJE) is an herbal prescription used in traditional Oriental medicine for treating cerebral infarction by reducing ischemic damage.
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Modeling the caspase cascade would suggest molecular locations where one might alter the necrosis/apoptosis balance and reducing ischemic damage [33].
Importantly, the equation predicts that both the restoration of MBF, and of capillary flow patterns, represent key aspects of reducing ischemic damage and reperfusion injury after myocardial ischemia.
Collectively, these findings show that Vitamin B therapy can reverse defects in cellular autophagy and ER stress due to HHcy; and thus may be a potential treatment to reduce ischemic damage caused by stroke in patients with HHcy.
Drugs that block MMP activity, or are free radical scavengers, significantly reduce ischemic damage.
Intracerebral administration of the CDK inhibitor flavopiridol significantly reduced ischemic damage during focal and global stroke [39], [40].
CINODs may also reduce ischemic damage to compromised myocardial tissue.
Several studies suggested that VEGF reduces ischemic damage via ERK-1/2 dependent pathways [ 11, 13].
Furthermore, systemic injection of SOD was used previously to prevent ROS production following global forebrain ischemia [ 53], a protocol which efficiently reduced ischemic damage.
We report a technique of selective cerebral and myocardial perfusion with the aim to reduce ischemic damage to brain and heart.
For example, DHA and EPA can ultimately increase arrhythmic thresholds, increase the threshold of ventricular fibrillation, increase heart rate variability, reduce ischemic damage, and favorably affect autonomic tone [ 30- 32].
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