Sentence examples for by reducing cell viability from inspiring English sources

Henceforth, CS/PLA AQ NPs demonstrated a strong antitumor activity in vitro by reducing cell viability, inducing cell necrosis, decreasing the negative surface charge and mitochondrial membrane potential, and fragmenting DNA.

In contrast, the enforced down-regulation of these miRNAs has suppressed TGF-β-induced EMT and subsequently sensitized breast cancer cells to taxol by reducing cell viability and invasiveness (Kong et al. 2008; Mei et al. 2010).

Thus, in the current work, we investigated the mutagenic effect of phototreatments at sublethal doses (reducing cell viability by <2 log10 units) by evaluating the appearance of mutants carrying resistance to rifampicin.

CC50 was the concentration reducing cell viability by 50% relative to controls.

We also show that ZSTK474 can enhance the effects of Rapamycin on reducing cell viability, by inhibition of Akt pathways.

In the absence of 5-FU, the knockdown of SphK1 in HCT116 cells by siRNA reduced cell viability by 35% compared with treatment with control siRNA, indicating that SphK1 normally maintains colon tumor cell survival.

Overexpression of RCAN1 by adenovirus reduced cell viability in lymphoma Raji cells and restrained the growth of lymphoma transplants in mice.

From the results, decreased UGT1A expression enhanced the sensitivity toward ganetespib treatment, as revealed by reduced cell proliferation and reduced cell viability.

At 100 μ M, the compound allowed continued growth for 1 h, but then suspended growth, decreased the stationary phase population by ∼15%, and reduced cell viability by 0.5- to 1-log over 24 h (Supplementary Fig. S4A, C).

To determine the mechanism by which these NSAIDs reduce cell viability, we assayed treated cells for evidence of apoptosis by utilizing Annexin V staining, and explored expression of mediators of apoptosis including caspase activity and levels of Bax and Bcl2.

Unlike microtubule binding agents, KT-NB inhibits cell proliferation and reduces cell viability by two mechanisms: first, by inducing multipolarity; second, by disrupting chromosome alignment during metaphase.