An adaptive response by S. aureus of reducing cell surface hydrophobicity was also observed.
First, we confirmed the effectiveness of 2F-Fuc to reduce cell surface fucose in T84 cells by showing that it caused a reduction in binding of UEA-1.
Finally, the mobility of α7-nAChRs was regulated by global network activity, with chronic application of TTX resulting in increased mobility and reduced cell surface expression.
Alternatively, cell density may suppress protein transduction by reducing cell size and/or available surface area [ 25].
The TC10 mutants, TCDN and TC10CA, equally reduced cell-surface AMPARs by ∼50% but did not significantly affect AMPAR trafficking through the secretory pathway.
Treatment of GIST cell lines with SR1 reduces cell-surface KIT expression, suggesting that mAb-induced KIT down-regulation may be a mechanism by which SR1 inhibits GIST growth.
While we did not measure competition between our Synura strains, it is conceivable that colony aggregation and increasing colony size could incur a fitness cost on individual cells by reducing exposed cell surface area and impairing the ability of individuals to acquire nutrient resources.
One possible mechanism for this is by reducing the cell surface proteolytic activities required for breaking and making cell-matrix adhesions during migration [ 20].
First, MCTS per se limit CTL capacity of recognising HLA class I restricted antigens by reducing exposed cell surfaces.
