Sentence examples for by reducing cell proliferation from inspiring English sources
Together, our results suggest that small molecule inhibitors of TGF-beta receptors may offer a novel therapy for malignant gliomas by reducing cell proliferation, angiogenesis, and motility.
However, restoring TDAG8 gene expression modulated the U937 cell response to mild extracellular acidosis and physiological pH by reducing cell proliferation.
Recently, silencing E2F-1 effectinhibitedibited gastric cancer progression by reducing cell proliferation and increasing apoptosis [64] suggesting an oncogenic function.
Our previous studies demonstrated that the complete absence of the Sp4 gene impaired postnatal development of hippocampal dentate gyrus by reducing cell proliferation, dendritic growth, and dendritic arborization in Sp4 null mutant mice [5].
Interestingly, increased DAX-1 cellular content affected MCF-7 population number by reducing cell proliferation rate.
These findings indicate that pitavastatin significantly suppresses FCA, at least in part, by inducing apoptosis and by reducing cell proliferation.
Similarly, addition of CYT387 (1 μM) sensitised the isolated ascites-derived tumor cells to paclitaxel by significantly reducing cell proliferation by approximately ~50-90 ~50-90er than that obtained by paclitaxel alone treatment (Ascites 13–15, Table 1).
Thus, hypoxia during pregnancy might affect facial development by increasing apoptosis or reducing cell proliferation.
More interestingly, in PTEN-deficient UM-UC-3 cells, addition of wortmannin synergistically (P<0.01) enhanced the toxicity of rapamycin, reducing cell proliferation by 40% when compared with rapamycin alone.
The cell numbers were thereafter counted with a hemocytometer, and the growth inhibition rate was plotted to determine the IC50 value, which stands for the drug concentration necessary for reducing cell proliferation by 50%.
In mouse fibroblasts we showed that solely si-RNA mediated ERK2 knock-down reduced cell proliferation by itself, however when ERK2 levels were clamped down, ERK1 knock-down became effective at reducing cell proliferation.
