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In tomato, we showed that the null mutation in SlTRM5 genetically interacted with ovate and sov1 to suppress the phenotype to a round shape primarily by reducing cell division in the proximo-distal direction.
This is consistent with the results presented in Table 2, indicating that wounding and MeJA reduce leaf growth by reducing cell division.
We could improve on this aspect of our model by reducing cell division in the very tip of the sprout, which is in agreement with the observation that mainly stalk cells located just behind the tip of the sprout proliferate.
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Loss of human VRK1 by siRNA reduces cell division [5], and in C. Elegans the inactivation of its homolog gene results in embryonic death and arrested growth in adults [6].
This study brings in new lights into the mechanisms evoked by both docetaxel and lovastatin to reduce cell division and increase apoptotic cell death.
As depicted in Figure 4B, BSO treated cells exhibited considerably reduced cell division rates evidenced by an increased retention of fluorescence.
This is supported by partial silencing of GSL1 in potato using antisense approaches that resulted in plants with reduced height and smaller leaves resulting from reduced cell division, altered leaf metabolism and cell wall composition [ 32].
Over-expression of let-7 miRs alters cell cycle progression and reduces cell division in lung cancer cells[30] and causes cell cycle arrest by directly regulating the gene Cdc34 in human fibroblasts[33].
The reason, he said, is probably because such diets reduce cell division, the prime source of cancer risk.
Results in Table 2 suggested that wounding may reduce cell division in leaves.
A decrease in the former will reduce DNA biosynthesis and thereby reduce cell division.
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