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In view of the 30 events observed, we did not strictly follow the classical rule of a minimum of 10 outcome events per predictor variable in the multivariable analysis [29], but our analysis fulfilled the minimum of 5 events per predictor variable proposed by recent simulation studies [30].
We speculate that the hydrophobic hydration of the ice binding surface is involved in initial protein-ice recognition by lowering the kinetic barrier as also suggested by recent simulation studies [13], [14].
The ability to noninvasively measure MTL activity is further supported by recent simulation studies (Quraan et al., 2011; Mills et al., 2012) and simultaneous iEEG/MEG recordings of hippocampal oscillations (Dalal et al., 2013; Staudigl and Hanslmayr, 2013).
In view of the 30 events observed, we did not strictly follow the classical rule of a minimum of 10 outcome events per predictor variable in the multivariable analysis [ 29], but our analysis fulfilled the minimum of 5 events per predictor variable proposed by recent simulation studies [ 30].
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For example, previous work by Kim and Stephan (1999) analyzed a single locus under a constant selection coefficient, using a diffusion approximation, and two recent simulation studies employed forward simulations with loci parameterized by constant selection coefficients to obtain power estimates (Baldwin-Brown et al. 2014; Kofler and Schlotterer 2014).
For example, some recent simulation studies can be found in [1, 18].
The performance of these two new methods is surveyed via previous and recent simulation studies.
To check these models, we compared these models MSE in both previous and recent simulation studies.
Two recent simulation studies concluded that improved HIV detection and pre-treatment CD4 monitoring in resource-poor settings could save several life-years per person taking antiretroviral treatment and could be cost-effective by preventing opportunistic infections [11], [12], [13].
Recent simulation studies suggest that transcriptional networks inferred from gene expression data alone can be considerably obscured by spurious interactions when the number of observations is small or the quality of the data is poor (Husmeier, 2003).
Moreover, recent simulation studies from Möhring et al. [ 38] showed that designs including rows and columns outperformed one-dimensional blocking.
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