Sentence examples for by rational screening of from inspiring English sources

A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations.

The human wild-type (R482) ABCG2-transfected cells were used for rational screening of inhibitory acridones.

The idea behind EMICs is clear and straightforward, but the huge pool of variables in its synthesis and characterization requires some rational screening strategies.

Take the one produced by Rational Investors, of Peabody, Mass.

The targeting of virulence systems of pathogens, by rational drug design against a given target, or by random screening of a library of compounds inhibiting the transport of the virulence system, is a new strategy [37], [47].

A Rho-specific inhibitor named rhosin, was recently identified by rational design and virtual screening using published structures of protein : protein interactions of RhoA and its GEF leukaemia-associated RhoGEF (LARG) (Shang et al., 2012).

We believe that our approach of antibody library generation followed by rational and science-based library screening, significantly contributes to selecting an optimal final product.

By rational design and selection of biomaterials, we incorporated multiple functional moieties in each layer compartment.

Such modifications can be achieved either by rational redesign, which requires knowledge of the enzyme structure, or by random mutagenesis methods followed by screening.

Those small‐molecule modulators can either be discovered by extensive and resource‐intensive screening campaigns or by rational design approaches.

The Senate was formed less by rational argument than by threats of treason and war.